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The Catawba Native Americans were the first known historic tribe to settle Mecklenburg County (in the Charlotte area) and were first recorded around 1567 in Spanish records. By 1759 half the Catawba tribe had died from smallpox, which was endemic among Europeans, because the Catawba had not acquired immunity to the new disease. At the time of their largest population, Catawba people numbered 10,000, but by 1826 their total population had dropped to 110. The European-American city of Charlotte was developed first by a wave of migration of Scots-Irish Presbyterians, or Ulster-Scot settlers from Northern Ireland, who dominated the culture of the Southern Piedmont Region. They made up the principal founding European population in the backcountry.