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The area in which the city of Fort Lauderdale would later be founded was inhabited for more than two thousand years by the Tequesta Indians. Contact with Spanish explorers in the 16th century proved disastrous for the Tequesta, as the Europeans unwittingly brought with them diseases, such as smallpox, to which the native populations possessed no resistance. For the Tequesta, disease, coupled with continuing conflict with their Calusa neighbors, contributed greatly to their decline over the next two centuries. By 1763, there were only a few Tequesta left in Florida, and most of them were evacuated to Cuba when the Spanish ceded Florida to the British in 1763, under the terms of the Treaty of Paris (1763), which ended the Seven Years' War. Although control of the area changed between Spain, United Kingdom, the United States, and the Confederate States of America, it remained largely undeveloped until the 20th century.